A³-Coupling catalyzed by robust Au nanoparticles covalently bonded to HS-functionalized cellulose nanocrystalline films

• Jian-Lin Huang,
• Derek G. Gray and
• Chao-Jun Li

Beilstein J. Org. Chem. 2013, 9, 1388–1396, doi:10.3762/bjoc.9.155

• ) either in water or without solvent. Most importantly, the catalyst could be used repetitively more than 11 times without significant deactivation. Our strategy also promotes the use of naturally renewable cellulose to prepare reusable nanocomposite catalysts for organic synthesis. Keywords: A3-coupling

• reaction; cellulose nanocrystallites (CNCs) films; gold catalysis; water or without solvent; Introduction Organic synthesis is usually performed in organic solvents; however, from a green chemistry perspective, evaporation and discharge of organic solvents not only generates chemical waste but also causes

• immobilized on the HS-functionalized CNCs. The novel Au@SH-CNC nanocomposite catalyst exhibited an excellent catalytic activity in the three-component coupling reaction of aldehyde-alkyne-amine (A3-coupling) either in water or without solvent, and could be used repetitively, which could reduce the cost and